Intrasaccular
Flow Diversion

Flexibility in design
Intrasaccular
Flow Diversion
Flexibility in design
Intrasaccular
Flow Diversion
Stability in mind
Intrasaccular
flow diversion
Flexibility in design

EndoStream develops aneurysm devices,
utilizing self-conforming scaffolds that adapt to an aneurysm’s unique shape
and provide maximal neck metal coverage

NautilusTM

A-traumatic, self-conforming intrasaccular flow diverter

Maximizing neck coverage and enhancing coil stability,
to optimize intrasaccular thrombosis and enable progressive occlusion 

The Nautilus Intrasaccular System is CE marked and available for sale in Europe.
The Nautilus™ is not approved for sale or distribution in the US and is limited by U.S. law to investigational use.
Please read IFU before use and for additional info on indications, contraindications, warnings, and precautions.

The Nautilus Edge

Self-conforming structure

adapts to various neck anatomies

maximal metal coverage

promotes intrasaccular thrombosis
& endothelial remodeling

No intraluminal components

eliminates the need for antiplatelet therapy

A-traumatic deployment

enhances physician confidence

Thin delivery profile

reaches the smallest vessels
by using any .0165" microcatheter

Entire device is radiopaque

maximizes visibility at all times

Self-conforming structure

adapts to various neck anatomies

maximal metal coverage

promotes intrasaccular thrombosis
& endothelial remodeling

No intraluminal components

eliminates the need for antiplatelet therapy

A-traumatic deployment

enhances physician confidence

Thin delivery profile

reaches the smallest vessels
by using any .0165" microcatheter

Entire device is radiopaque

maximizes visibility at all times

About Us

EndoStream is dedicated to developing safe and effective solutions
that significantly improve clinical outcomes for patients suffering from brain aneurysms

Danel Mayer

Founder & CEO

Danel is the founder and CEO of EndoStream Medical. Before EndoStream, he founded Rapid Medical (now held by MicroPort), where he spent five years leading the company from inception to clinical trials. Prior to that he spent several years in the San Francisco Bay Area working as a product manager at Concentric Medical (acquired by Stryker) and as a business-development intern at Kerberos (acquired by ev3). Danel also previously worked as a lending associate for healthcare companies at the corporate finance division of Israel’s largest bank.

Danel holds an MBA from the Haas School of Business at UC Berkeley and a dual Bachelor’s from Tel Aviv University in Psychology and Economics.

Alon May

Founder & CTO

Alon is the founder and CTO of EndoStream Medical. He has vast experience in leading complex engineering projects in medical device startups, overseeing the clinical need definition, characterization, design, and validation. Prior to co-founding EndoStream he served in managerial roles at Superdimension (a multidisciplinary system for navigation in the lungs acquired by Covidien) and Executive roles as VP Engineering and Operations at EndoCross (a catheter-based system for treating coronary and peripheral CTO) and CEO at Intratech Medical (a thrombectomy catheter for ischemic stroke).

Alon holds a B.Sc. in Mechanical Engineering from Israel Institute of Technology and he is a Lieutenant commander (reserve) in the Israeli navy.

J Mocco, MD, MS

Medical Advisor

Dr. Mocco is a cerebrovascular and endovascular neurosurgeon with clinical interests in stroke, brain aneurysms, subarachnoid hemorrhage, arteriovenous malformations, cavernous malformations, carotid artery stenosis, intracranial stenosis, and brain tumors. He serves as a Professor and Senior System Vice Chair in the Department of Neurosurgery at Mount Sinai, as well as Director of the Cerebrovascular Center. Dr. Mocco was previously Associate Professor of Neurological Surgery, Radiology, and Radiological Sciences at Vanderbilt University Medical Center.

Dr. Mocco has published more than 525 peer-reviewed publications, edited three texbooks on neurosurgical techniques, and runs numerous national and international clinical trials to improve the treatment of patients with cerebrovascular disease.

Michal Yahav

Director of Quality and Regulatory Affairs

Micahl has over sixteen years of professional experience in the medical device and pharmaceutical industries, including four years as a consultant and seven years as a senior QA/RA manager. She has previously established comprehensive quality management systems in startup companies and managed CE and FDA approval processes of class III medical devices. She also served as a project manager – process development and validations.

Michal holds a Master’s degree in Biotechnology from the Hebrew University in Jerusalem.

Hadas Abalia

Clinical Trials Manager

Hadas brings years of experience in conducting and managing clinical trials in various medical centers and healthcare companies. She has strong project management skills, leading projects & complex processes from idea to execution. Prior to joining EndoStream, Hadas served as a clinical project specialist at Syqe Medical and as a Clinical Research Manager at Rabin Medical Center.
Hadas holds an MBA from Bar-Ilan University and a B.sc. in Nutritional Science from Tel-Hai college.

Alejandro Berenstein, MD

Medical Advisor

Dr. Berenstein is one of the founding fathers of Interventional Neuroradiology. He is a Clinical Professor and Director of the Pediatric Cerebrovascular Program at the Mount Sinai Health System in New York City.

Dr. Berenstein contributed to over 180 peer-reviewed publications, more than 40 chapters in the field, and 9 books. He is the past President of the World Federation of Interventional and Therapeutic Neuroradiology (WFITN), the Society of NeuroInterventional Surgery (SNIS) and the Latin-American Society of Neuroradiology (SILAN).

Danel Mayer

Founder & CEO

Danel is the founder and CEO of EndoStream Medical. Before EndoStream, he founded Rapid Medical (now held by MicroPort), where he spent five years leading the company from inception to clinical trials. Prior to that he spent several years in the San Francisco Bay Area working as a product manager at Concentric Medical (acquired by Stryker) and as a business-development intern at Kerberos (acquired by ev3). Danel also previously worked as a lending associate for healthcare companies at the corporate finance division of Israel’s largest bank.

Danel holds an MBA from the Haas School of Business at UC Berkeley and a dual Bachelor’s from Tel Aviv University in Psychology and Economics.

Alon May

Founder & CTO

Alon is the founder and CTO of EndoStream Medical. He has vast experience in leading complex engineering projects in medical device startups, overseeing the clinical need definition, characterization, design, and validation. Prior to co-founding EndoStream he served in managerial roles at Superdimension (a multidisciplinary system for navigation in the lungs acquired by Covidien) and Executive roles as VP Engineering and Operations at EndoCross (a catheter-based system for treating coronary and peripheral CTO) and CEO at Intratech Medical (a thrombectomy catheter for ischemic stroke).

Alon holds a B.Sc. in Mechanical Engineering from Israel Institute of Technology and he is a Lieutenant commander (reserve) in the Israeli navy.

J Mocco, MD, MS

Medical Advisor

Dr. Mocco is a cerebrovascular and endovascular neurosurgeon with clinical interests in stroke, brain aneurysms, subarachnoid hemorrhage, arteriovenous malformations, cavernous malformations, carotid artery stenosis, intracranial stenosis, and brain tumors. He serves as a Professor and Senior System Vice Chair in the Department of Neurosurgery at Mount Sinai, as well as Director of the Cerebrovascular Center. Dr. Mocco was previously Associate Professor of Neurological Surgery, Radiology, and Radiological Sciences at Vanderbilt University Medical Center.

Dr. Mocco has published more than 525 peer-reviewed publications, edited three texbooks on neurosurgical techniques, and runs numerous national and international clinical trials to improve the treatment of patients with cerebrovascular disease.

Michal Yahav

Director of Quality and Regulatory Affairs

Micahl has over sixteen years of professional experience in the medical device and pharmaceutical industries, including four years as a consultant and seven years as a senior QA/RA manager. She has previously established comprehensive quality management systems in startup companies and managed CE and FDA approval processes of class III medical devices. She also served as a project manager – process development and validations.

Michal holds a Master’s degree in Biotechnology from the Hebrew University in Jerusalem.

Hadas Abalia

Clinical Trials Manager

Hadas brings years of experience in conducting and managing clinical trials in various medical centers and healthcare companies. She has strong project management skills, leading projects & complex processes from idea to execution. Prior to joining EndoStream, Hadas served as a clinical project specialist at Syqe Medical and as a Clinical Research Manager at Rabin Medical Center.
Hadas holds an MBA from Bar-Ilan University and a B.sc. in Nutritional Science from Tel-Hai college.

Alejandro Berenstein, MD

Medical Advisor

Dr. Berenstein is one of the founding fathers of Interventional Neuroradiology. He is a Clinical Professor and Director of the Pediatric Cerebrovascular Program at the Mount Sinai Health System in New York City.

Dr. Berenstein contributed to over 180 peer-reviewed publications, more than 40 chapters in the field, and 9 books. He is the past President of the World Federation of Interventional and Therapeutic Neuroradiology (WFITN), the Society of NeuroInterventional Surgery (SNIS) and the Latin-American Society of Neuroradiology (SILAN).

See it in action

01.
Deployment of Nautilus

The Nautilus is completely radiopaque, and its visible shape demonstrates how its flexible, adaptive structure self-conforms to the aneurysm neck’s anatomy.

02.
Baseline angiogram

Showing an anterior communicating artery wide-neck aneurysm.

03.
End-of-procedure angiogram

The acute status of the ruptured aneurysm leads to suboptimal coil packing, which will be compensated for by the Nautilus over time.

04.
3-month follow-up

The Nautilus’s substantial metal coverage compensated for suboptimal coil packing and promoted in-sac thrombosis and endothelial reconstruction across the aneurysm neck, leading to complete obliteration of the aneurysm (Raymond Roy Class I).

Publications

July 2022

Intrasaccular neck-bridging: A technical note on Nautilus-assisted coiling of wide-necked cerebral aneurysms. Feasibility study, immediate and...

May 2022

Nautilus-Assisted Coil Occlusion for Treatment of a Ruptured Aneurysm at the Bifurcation of the Right Middle Cerebral Artery: Complete Occlusi...

July 2021

Nautilus-Assisted Coiling of an Unruptured Wide-Necked Aneurysm of the Posterior Communicating Artery

June 2021

Nautilus-assisted coil embolization for a complex AcomA wide-necked aneurysm in the setting of acute subarachnoid hemorrhage

Contact

Address:12 Hailan St., Or Akiva 3065201, Israel