Intrasaccular
Flow Diversion

Flexibility in design
Intrasaccular
Flow Diversion
Flexibility in design
Intrasaccular
Flow Diversion
Stability in mind
Intrasaccular
flow diversion
Flexibility in design

EndoStream develops aneurysm devices,
utilizing self-conforming scaffolds that adapt to an aneurysm’s unique shape
and provide maximal neck metal coverage

NautilusTM

A-traumatic, self-conforming intrasaccular flow diverter

Maximizing neck coverage and enhancing coil stability,
to optimize intrasaccular thrombosis and enable progressive occlusion 

The Nautilus Intrasaccular System is CE marked and available for sale in Europe.
The Nautilus™ is not approved for sale or distribution in the US and is limited by U.S. law to investigational use.
Please read IFU before use and for additional info on indications, contraindications, warnings, and precautions.

The Nautilus Edge

Self-conforming structure

adapts to various neck anatomies

maximal metal coverage

promotes intrasaccular thrombosis
& endothelial remodeling

No intraluminal components

eliminates the need for antiplatelet therapy

A-traumatic deployment

enhances physician confidence

Thin delivery profile

reaches the smallest vessels
by using any .0165" microcatheter

Entire device is radiopaque

maximizes visibility at all times

Self-conforming structure

adapts to various neck anatomies

maximal metal coverage

promotes intrasaccular thrombosis
& endothelial remodeling

No intraluminal components

eliminates the need for antiplatelet therapy

A-traumatic deployment

enhances physician confidence

Thin delivery profile

reaches the smallest vessels
by using any .0165" microcatheter

Entire device is radiopaque

maximizes visibility at all times

About Us

EndoStream is dedicated to developing safe and
effective solutions that significantly improve clinical outcomes
for patients suffering from brain aneurysms

Danel Mayer

Founder & CEO

Danel is the founder and CEO of EndoStream Medical. Before EndoStream, he founded Rapid Medical (now held by MicroPort), where he spent five years leading the company from inception to clinical trials. Prior to that he spent several years in the San Francisco Bay Area working as a product manager at Concentric Medical (acquired by Stryker) and as a business-development intern at Kerberos (acquired by ev3). Danel also previously worked as a lending associate for healthcare companies at the corporate finance division of Israel’s largest bank.

Danel holds an MBA from the Haas School of Business at UC Berkeley and a dual Bachelor’s from Tel Aviv University in Psychology and Economics.

Alon May

Founder & CTO

Alon is the founder and CTO of EndoStream Medical. He has vast experience in leading complex engineering projects in medical device startups, overseeing the clinical need definition, characterization, design, and validation. Prior to co-founding EndoStream he served in managerial roles at Superdimension (a multidisciplinary system for navigation in the lungs acquired by Covidien) and Executive roles as VP Engineering and Operations at EndoCross (a catheter-based system for treating coronary and peripheral CTO) and CEO at Intratech Medical (a thrombectomy catheter for ischemic stroke).

Alon holds a B.Sc. in Mechanical Engineering from Israel Institute of Technology and he is a Lieutenant commander (reserve) in the Israeli navy.

Efrat Carmi

Director of Human Resources

Efrat Carmi brings over 15 years of HR leadership experience in the tech and medical device sectors. Before joining EndoStream Medical, she led HR at Sight Diagnostics during a period of rapid growth and held key roles at Perion Network, Comverse, and Applied Materials. Her expertise spans organizational development, talent acquisition, and HR strategy. Efrat holds a B.A. in Behavioral Sciences and completed graduate studies in Organizational and Social Psychology at Ben-Gurion University.

Nathaly Fainer

Director of QA & RA

Nathaly has over 16 years of managerial experience in the MedTech industry. Prior to joining EndoStream, Nathaly held key positions at Perflow Medical (a neurovascular company), Dan-Mor (a disinfection-solutions company), Mediline (a pharmaceutical company) and Ethrog Biotechnologies Invitrogen (a DNA test-kits developer). 

Nathaly holds a B.Sc in Biotechnology from Tel-Hai Academic College and an M.A. in Quality Studies from the Department of Statistics, University of Haifa, Israel.

Noam Cohen

Director of Operations

Noam has over 18 years of experience establishing and leading Operations, Engineering and Manufacturing activities in the Medical and High-tech industries. Prior to joining EndoStream, he served in various managerial roles at Cardiac Implants (percutaneous transcatheter devices for the treatment of structural heart diseases) and PixCell Medical Technologies (devices for rapid blood test diagnostics).

Noam holds a B.Sc. in Mechanical Engineering from Braude Academic College of Engineering in Israel.

Zohar Bronshtine

Senior Director of Clinical Affairs

Zohar Bronshtine has over 20 years of experience in clinical affairs within the medical device industry. At EndoStream Medical, she leads global clinical trial strategy and execution. Previously, she served as Senior Director of Clinical Affairs at Magenta Medical, guiding first-in-human through pivotal trials and FDA submissions for a novel cardiovascular technology. Zohar holds an M.Sc. from the Sackler Faculty of Medicine, Tel Aviv University, and a B.A. in Physical Education with a focus on Cardiovascular Rehabilitation from the Zinman College at the Wingate Institute.

Yoav Mezape

Director of Research and Development

Yoav Mezape leads R&D at EndoStream Medical with over 16 years of experience in the med-tech industry. He previously held senior roles at Endospan, Nitiloop, and Filterlex Medical, overseeing the development of endovascular and catheter-based technologies. Yoav specializes in managing multidisciplinary teams and advancing projects from concept to commercialization. He holds a B.Sc. in Biomedical and Mechanical Engineering from the Technion – Israel Institute of Technology.

Caroleena Ram

QA Manager

Caroleena’s background includes QA and R&D roles in the food engineering sector, as well as quality and regulatory oversight positions with the Israeli Ministry of Health.

She joined EndoStream in 2021 as a QA Engineer and now serves as QA Manager, leading the company’s quality and compliance activities in line with international regulatory standards. At EndoStream, Caroleena has been instrumental in strengthening the Quality Management System, driving audits, overseeing supplier quality, and ensuring product compliance and release processes. Caroleena holds a B.Sc. in Food Science from Tel-Hai Academic College.

Danel Mayer

Founder & CEO

Danel is the founder and CEO of EndoStream Medical. Before EndoStream, he founded Rapid Medical (now held by MicroPort), where he spent five years leading the company from inception to clinical trials. Prior to that he spent several years in the San Francisco Bay Area working as a product manager at Concentric Medical (acquired by Stryker) and as a business-development intern at Kerberos (acquired by ev3). Danel also previously worked as a lending associate for healthcare companies at the corporate finance division of Israel’s largest bank.

Danel holds an MBA from the Haas School of Business at UC Berkeley and a dual Bachelor’s from Tel Aviv University in Psychology and Economics.

Alon May

Founder & CTO

Alon is the founder and CTO of EndoStream Medical. He has vast experience in leading complex engineering projects in medical device startups, overseeing the clinical need definition, characterization, design, and validation. Prior to co-founding EndoStream he served in managerial roles at Superdimension (a multidisciplinary system for navigation in the lungs acquired by Covidien) and Executive roles as VP Engineering and Operations at EndoCross (a catheter-based system for treating coronary and peripheral CTO) and CEO at Intratech Medical (a thrombectomy catheter for ischemic stroke).

Alon holds a B.Sc. in Mechanical Engineering from Israel Institute of Technology and he is a Lieutenant commander (reserve) in the Israeli navy.

Efrat Carmi

Director of Human Resources

Efrat Carmi brings over 15 years of HR leadership experience in the tech and medical device sectors. Before joining EndoStream Medical, she led HR at Sight Diagnostics during a period of rapid growth and held key roles at Perion Network, Comverse, and Applied Materials. Her expertise spans organizational development, talent acquisition, and HR strategy. Efrat holds a B.A. in Behavioral Sciences and completed graduate studies in Organizational and Social Psychology at Ben-Gurion University.

Nathaly Fainer

Director of QA & RA

Nathaly has over 16 years of managerial experience in the MedTech industry. Prior to joining EndoStream, Nathaly held key positions at Perflow Medical (a neurovascular company), Dan-Mor (a disinfection-solutions company), Mediline (a pharmaceutical company) and Ethrog Biotechnologies Invitrogen (a DNA test-kits developer). 

Nathaly holds a B.Sc in Biotechnology from Tel-Hai Academic College and an M.A. in Quality Studies from the Department of Statistics, University of Haifa, Israel.

Noam Cohen

Director of Operations

Noam has over 18 years of experience establishing and leading Operations, Engineering and Manufacturing activities in the Medical and High-tech industries. Prior to joining EndoStream, he served in various managerial roles at Cardiac Implants (percutaneous transcatheter devices for the treatment of structural heart diseases) and PixCell Medical Technologies (devices for rapid blood test diagnostics).

Noam holds a B.Sc. in Mechanical Engineering from Braude Academic College of Engineering in Israel.

Zohar Bronshtine

Senior Director of Clinical Affairs

Zohar Bronshtine has over 20 years of experience in clinical affairs within the medical device industry. At EndoStream Medical, she leads global clinical trial strategy and execution. Previously, she served as Senior Director of Clinical Affairs at Magenta Medical, guiding first-in-human through pivotal trials and FDA submissions for a novel cardiovascular technology. Zohar holds an M.Sc. from the Sackler Faculty of Medicine, Tel Aviv University, and a B.A. in Physical Education with a focus on Cardiovascular Rehabilitation from the Zinman College at the Wingate Institute.

Yoav Mezape

Director of Research and Development

Yoav Mezape leads R&D at EndoStream Medical with over 16 years of experience in the med-tech industry. He previously held senior roles at Endospan, Nitiloop, and Filterlex Medical, overseeing the development of endovascular and catheter-based technologies. Yoav specializes in managing multidisciplinary teams and advancing projects from concept to commercialization. He holds a B.Sc. in Biomedical and Mechanical Engineering from the Technion – Israel Institute of Technology.

Caroleena Ram

QA Manager

Caroleena’s background includes QA and R&D roles in the food engineering sector, as well as quality and regulatory oversight positions with the Israeli Ministry of Health.

She joined EndoStream in 2021 as a QA Engineer and now serves as QA Manager, leading the company’s quality and compliance activities in line with international regulatory standards. At EndoStream, Caroleena has been instrumental in strengthening the Quality Management System, driving audits, overseeing supplier quality, and ensuring product compliance and release processes. Caroleena holds a B.Sc. in Food Science from Tel-Hai Academic College.

See it in action

01.
Deployment of Nautilus

The Nautilus is completely radiopaque, and its visible shape demonstrates how its flexible, adaptive structure self-conforms to the aneurysm neck’s anatomy.

02.
Baseline angiogram

Showing an anterior communicating artery wide-neck aneurysm.

03.
End-of-procedure angiogram

The acute status of the ruptured aneurysm leads to suboptimal coil packing, which will be compensated for by the Nautilus over time.

04.
3-month follow-up

The Nautilus’s substantial metal coverage compensated for suboptimal coil packing and promoted in-sac thrombosis and endothelial reconstruction across the aneurysm neck, leading to complete obliteration of the aneurysm (Raymond Roy Class I).

Publications

December 2025

A rare aneurysm at a posterior communicating artery fenestration treated with the Nautilus Intrasaccular System: A case report

September 2025

How to use the Nautilus Intrasaccular System

March 2023

Four‐Year Follow‐Up on the First‐in‐Human Experience With Nautilus Intrasaccular System Assisted Coiling for Unruptured Intracranial A...

October 2022

Endovascular treatment of wide-necked intracranial aneurysms using the Nautilus Intrasaccular System: initial case series of 41 patients at a ...

July 2022

Intrasaccular neck-bridging: A technical note on Nautilus-assisted coiling of wide-necked cerebral aneurysms. Feasibility study, immediate and...

May 2022

Nautilus-Assisted Coil Occlusion for Treatment of a Ruptured Aneurysm at the Bifurcation of the Right Middle Cerebral Artery: Complete Occlusi...

July 2021

Nautilus-Assisted Coiling of an Unruptured Wide-Necked Aneurysm of the Posterior Communicating Artery

June 2021

Nautilus-assisted coil embolization for a complex AcomA wide-necked aneurysm in the setting of acute subarachnoid hemorrhage

Contact

Address:25 Tarshish St., Building A,
2nd Floor, P.O.B. 3127,
Caesarea 3070554, Israel